DDR1 depletion also reduced the transcript level of canonical Wnt target genes CD44, CCND1, LGR5 and AXIN2 involved in CRC stem cell properties (Vanharanta & Massague, 2013); however, it had no effect on ASCL2 and SLC12A2 (Fig EV4A). The gene discussed is CCND1; the disease is colorectal carcinoma.