Conversely, nilotinib hardly affected BCR Tyr177 phosphorylation in HCT116 shDDR1 cells that express DDR1 T701I (Fig 5D), suggesting that in CRC cells, this phosphorylation is directly mediated by the DDR1 kinase activity and does not involve ABL. The gene discussed is DDR1; the disease is colorectal carcinoma.