MYH9 and cancer: The targeting sites are also >300 kb from any identified microRNA and cancer-related gene, and are located outside of ultra-conserved regions and long noncoding RNAs, Importantly, all heterozygous mice produced from the genetic replacement strategy shown in Fig 1 were normal, suggesting no influence on these flanking genes by targeted integration of exogenous cassettes at MYH9 exon 2.