Another saponin species, SO-1861 from the roots of Saponaria officinalis also significantly augmented the therapeutic efficacy of EGF-Sap (Sap3-EGF, i.e., Saporin isoform 3 fused to epidermal growth factor) against the EGFR-expressing TSA mammary carcinoma cell line TSA growing in syngeneic mice [97]. This evidence concerns the gene EGF and breast carcinoma.