TNF and Cognitive impairment: In line with the evaluation of small molecules active on neuroinflammatory processes induced by traumatic brain injury, it has been reported that administration of MW01-2-151WH (MW151), a small molecule inhibiting the production of proinflammatory cytokines, such as interleukin-1 beta (IL-1β) and tumor necrosis factor alpha (TNFα) but not blocking the release of anti-inflammatory cytokines, such as interleukin-10 (IL-10), was able to suppress cytokine acute up-regulation and downstream cognitive impairment [114,115].