Virus-induced DNA hypermethylation is commonly found on several tumor suppressor genes including RASSF1A, p16 (also known as cyclin dependent kinase inhibitor 2A (CDKN2A)), TP73, p21 (also known as CDKN1A), and retinoblastoma-associated protein (pRb) (Table 1). This evidence concerns the gene CDKN1A and neoplasm.