ERBB2 and cancer: Amongst the heat-shock protein family, the heat-shock protein 90 (HSP90) is the most widely studied target for cancer therapy, being important to the maturation and stabilization of different client oncoproteins such as Akt, Bcr-Abl, HER-2/ErbB2, Raf-1, CDK, survivin, and mutated p53 [6].