The XO activity of hyperuricemic rats treated with high dose of 400 mg/kg PR-ME extract from P. rubra flower was reduced significantly to 7.18 ± 0.30 mU/mL 43.77%, whereas with dose of 200 mg/kg reduced the XO activity significantly at 8.73 ± 0.52 mU/mL( by 31.64%) as compared to the gout control group. This evidence concerns the gene XDH and gout.