KRT18 and neoplasm: Statistical analysis indicated that CK18 overexpression was highly relevant with tumor stage (OR = 2.83, 95%CI: 1.32–6.06, P=0.007) (Supplementary Figure S2A), nodal status (OR = 2.11, 95%CI: 1.28–3.46, P=0.003) (Supplementary Figure S2B), and tumor grade (OR = 1.82, 95%CI: 1.46–2.27, P<0.00001) (Supplementary Figure S2C).