We thus selected all genes that were significantly dysregulated in tumours of both mouse models (“Pten model (all lobes) and p53/Rb model” in Fig EV1B) and in human prostate cancers and filtered them using The Drug Gene Interaction Database (DGIdb; http://dgidb.genome.wustl.edu/) to enrich for genes that are predicted to be druggable (Griffith et al, 2013; Fig 3C). This evidence concerns the gene TP53 and prostate cancer.