Westerterp et al72 demonstrate that deficiency of ABCA1/ABCG1 in endothelial cells accelerates atherosclerosis, and they suggested that endothelial cell–derived ABCA1/ABCG1 plays a role in preservation of endothelial NO synthase activity and suppression of endothelial inflammation. Here, ABCG1 is linked to atherosclerosis.