For instance, the outstanding PheWAS association between disorders of iron metabolism and the SNP rs1165151 in SLC17A3 locus was not consistent with a pleiotropic model, and further examination found the SUA-associated SNP rs1165151 was located in LD (r2=0.24), with the rs17342717 variant in SLC17A1 locus, which was strongly associated with disorders of iron metabolism (P=1.69e-129). This evidence concerns the gene SLC17A3 and metabolic disease.