Our analysis rejected the null hypothesis of a pleiotropic model for the shared genetic association between SUA level and disorders of iron metabolism at the SLC17A3 locus (rs1165151) (PHEIDI =5.54e-28); we identified a different causal variant (rs17342717 in SLC17A1) that was in LD with the SNP rs1165151 (r2=0.24) and strongly associated with the disorders of iron metabolism (P=1.69e-129) (see online supplementary figure S13). This evidence concerns the gene SLC17A3 and metabolic disease.