SH2B3 and autoimmune disease: The strongest pleiotropic locus was the ATXN2/SH2B3, where three SNPs (rs653178, rs4766578 and rs3184504) in near-complete LD (r2=0.99) were tagged as the lead SNPs associated with 10 disease groups/outcomes as a cluster of cardiovascular diseases and autoimmune disorders (see online supplementary figure S10).