Similarly, for the associations between the SLC17A3 locus (rs1165151) and coeliac disease (PHEIDI =6.51e-16) (see online supplementary figure S13), and the GCKR locus (rs1260326) and hypercholesterolaemia (PHEIDI =3.27e-11) (see online supplementary figure S14), the pattern of shared regional genetic association was more consistent with a genetic linkage model, and the SNP with the smallest P value was tagged as an index of the distinct causal variant affecting the examined disease outcome. This evidence concerns the gene SLC17A3 and Hypercholesterolemia.