Other potential pleiotropic effects included the associations of BCAS3 locus (rs2079742) with essential hypertension (PHEIDI =0.10) and hypertensive disease (PHEIDI =0.09) (see online supplementary figure S11), the associations of ABCG2 locus (rs2231142) with varicose veins of lower extremity (PHEIDI =0.32) (see online supplementary figure S12), and the association of SLC17A3 locus (rs1165151) with poisoning by antibiotics (PHEIDI =0.26) (see online supplementary figure S13). This evidence concerns the gene ABCG2 and hypertensive disorder.