For example, rs653178 (ATXN2/SH2B3 locus) was previously reported to be associated with diastolic blood pressure,32 myocardial infarction,33 peripheral artery disease,34 coeliac disease35 and serum thyroid peroxidase antibody levels.36 In our PheWAS, this SNP was statistically significantly associated with the same phenotypes (ie, coeliac disease, myocardial infarction) or similar phenotypic groups (ie, hypertension, circulatory and heart diseases, hypothyroidism and other disorders of thyroid). This evidence concerns the gene SH2B3 and heart disorder.