The tests of anxiety-like behavior were somewhat inconsistent: increased time in open arms of the zero maze in 3M mice indicated reduced anxiety-like behavior; however, 9M Plp1-null mice exhibited increased anxiety-like behavior in the open field (Table 5), and, although this was not a statistically significant effect, Plp1-null mice exhibited an increased latency to explore the puzzle box entry (Figure 6—figure supplement 1C,D). Here, PLP1 is linked to Anxiety.