These isolated transaminase elevations are associated with an ALT/AST ratio > 1 and a normal bilirubin level, peaking 4–12 days after treatment, and have been reported following multiple antimalarial compounds in both falciparum and vivax malaria models.29,30 Similar elevations have been observed after sporozoite malaria challenge.31,32 Delayed transaminase elevation may be attributed to the antimalarial compound, the use of acetaminophen for symptom relief,33 the malaria parasite, or host factors associated with parasite clearance. The gene discussed is GPT; the disease is malaria.