Given recent evidence indicating that GLP‐1R activation is neuroprotective in cellular and mouse models of AD 5, 17, 22, 23, 25, 27, 28, 58, 59, we first sought to determine whether liraglutide might prevent the loss of synapses induced by AβOs in mature neuronal hippocampal cultures. The gene discussed is GLP1R; the disease is Alzheimer disease.