ASCT2 is frequently upregulated in multiple cancers and inhibition of ASCT2-mediated glutamine uptake by pharmacological inhibitors of ASCT2 or by shRNA-mediated knockdown of ASCT2 has been shown to successfully inhibit cancer cell growth and proliferation (Cui et al. 2015; Gong et al. 2014; Hassanein et al. 2013, 2015; Lu et al. 2016; van Geldermalsen et al. 2016). The gene discussed is SLC1A5; the disease is cancer.