In acute mycobacterial infection, the inflammatory response of monocytes and macrophages is damped by the secretion of large amounts of IL-10 from neutrophils (Zhang et al. 2009), a phenomenon also observed in a model of septic peritonitis where adoptive transfer of WT but not IL-10−/− neutrophils decreases the release of TNF by monocytes (Ocuin et al. 2011). The gene discussed is IL10; the disease is peritonitis.