In the model adjusted for age, race/ethnicity, sex, HIV transmission category, smoking, enrollment and before enrollment nadir CD4+ T cells, enrollment and prior maximum HIV load, the difference in mean CRAE between those with and without AMD was 5.4 μm (95% confidence interval [CI] 2.3–8.5; P = 0.001), and the difference in mean CRVE between those with and without AMD was 6.0 μm (95% CI 1.4–10.6; P = 0.01). This evidence concerns the gene CD4 and age-related macular degeneration.