Notably, one of the most important overexpressed cytokine in SLE, interferon (IFN)-γ, upregulates several pro-atherogenic processes such as the production of lipid mediators, platelet-activating factors and eicosanoids, antigen presentation, and synthesis of TNF-α and IL-1 (45). The gene discussed is IL1B; the disease is systemic lupus erythematosus.