For SLE, it has been developed the Predictors of Risk for Elevated Flares, Damage Progression, and Increased Cardiovascular Disease in SLE (PREDICTS) model, which includes four inflammatory biomarkers (homocysteine, piHDL, TWEAK, and leptin) and two risk factors (age and diabetes) (66). This evidence concerns the gene LEP and systemic lupus erythematosus.