No effects on atherosclerosis biomarkers, such as homocysteine, high-sensitivity CRP, soluble vascular cell adhesion molecule 1, P-selectin, and thrombomodulin (158) The association with HCQ has synergistic thromboprotective effect (162, 163) Reduces CVE in aPL positive patients (164). This evidence concerns the gene THBD and atherosclerosis.