Some authors have questioned this conclusion showing that some new developed molecularly defined murine models of immunodeficiency such as GM-CSF/IFN-γ−/− doubly deficient and GM-CSF/IL-3/IFN-γ−/− triply deficient mice, display a higher incidence of many tumor types apparently supporting the immunosurveillance predictions. This evidence concerns the gene IL3 and immune system disorder.