Therefore, a possible dysregulation of the nuclear factor kappa‐light‐chain‐enhancer of activated B cells (NF‐κB) signaling pathway emerged, a pathway already associated to retinal degeneration 39, 40, along with fatty acid metabolism, known to be one of the most involved pathways in RP 41 and its particular forms, such as Stargardt syndrome 42. This evidence concerns the gene NFKB1 and retinal degeneration.