INSR and Noonan syndrome: Furthermore, three signaling pathways were predicted to be altered by selected miRNA dysregulation: insulin receptor signaling, possibly related to glucose sequestration by RPE in RP dominant subjects 45, SOS‐mediated signaling, already associated to ocular manifestations in Noonan syndrome 46, 47, and Hedgehog signaling, whose impairments could lead to ciliary trafficking defects 48.