Notably, we found that BEL‐7402 transfected with the miR‐204‐5p inhibitor and SIX1 siRNA partially reversed the effects of anti‐miR‐204‐5p, which suggests that miR‐204‐5p might regulate other pathways to exert its functions in HCC proliferation and requires further investigation. This evidence concerns the gene SIX1 and hepatocellular carcinoma.