Furthermore, by down-regulating the bioactivity of TGF-β1, DCN decreases the abundance of oncogenic microRNA (miR-21), a transcriptional inhibitor of a tumour suppressor named programmed cell death protein 4 (PDCD4), in a TLR2/4 independent manner [45] (Figure 3). This evidence concerns the gene TGFB1 and neoplasm.