MTOR and neoplasm: Goyal et al [90] noted the following: DCN inhibited anti-autophagic signalling by suppressing PI3K/Akt/mTOR/p70S6K activity with concurrent activation of pro-autophagic AMPK-mediated signalling cascades; induced endothelial cell autophagy; reduced the growth of blood vessels in the tumour stroma; and prevented the metastasis and spread of tumour cells.