Moreover, each LRR is characterized by unique biological feature that is specific to the known bioactivities of DCN: LRR V/VI assists in DCN binding to VEGFR2 [11]; LRR VII, the collagen-binding sequence is present on the inner surface of the solenoid [12] and directly mediates the interaction between DCN and type I collagen; LRR XII binds to CCN2/CTGF [13]; and LRR XI is known as the “ear” repeat whose truncations or mutations may cause congenital stromal corneal dystrophy [14, 15]. This evidence concerns the gene CCN2 and stromal corneal dystrophy.