The first-generation EGFR-TKIs erlotinib (molecular weight (MW): 394 Da) and gefitinib (MW: 446 Da) have been approved by the United States Food and Drug Administration (FDA) for the treatment of metastatic NSCLC with EGFR mutations [37, 38] (Table 3). This evidence concerns the gene EGFR and non-small cell lung carcinoma.