AKT1 and acute lymphoblastic leukemia: In addition to the well-known oncogenic NOTCH signaling pathway, there are many other biologically relevant pathways controlling cell growth, proliferation and survival, such as PI3K/AKT [44], NF-κB [45, 48], cAMP/PKA [57], and JAK/STAT pathway [58]; all of whose interactions with miRNAs also play important roles in T-ALL pathology.