Moreover, it was confirmed that miR-223 mediated overexpression of TAL1-induced growth of T-ALL cells through the direct inhibition of the expression of tumor suppressor, FBXW7. FBXW7 has been shown to be able to repress MYC, MYB, NOTCH1, and CYCLIN E expression. This evidence concerns the gene NOTCH1 and acute lymphoblastic leukemia.