For example, in a study of examination of the roles of three mir-181 genes (mir-181ab1, mir-181ab2 and mir-181cd) in normal thymocyte development and in T-ALL development [56], it was found that deletion of mir-181ab1, but not mir-181ab2 and mir-181cd, effectively inhibited NOTCH1-induced T-ALL [56]. The gene discussed is NOTCH1; the disease is acute lymphoblastic leukemia.