WIF1 and colorectal carcinoma: Our results showed a significant association of WIF1 methylation with CRC risk in Asians, Europeans and Africans (Asians: 579 cases versus 417 controls, P < 0.001, OR = 64.33, 95% CI = 35.34-117.09, Europeans: 758 cases versus 486 controls, P < 0.001, OR = 11.83, 95% CI = 5.06-27.64, Africans: 83 cases versus 43 controls, P < 0.001, OR = 11.16, 95% CI = 4.54-27.47, Supplementary Figure 1).