WIF1 and colorectal carcinoma: There was a sensitivity of 0.71 (95% CI: 0.67-0.75), a specificity of 0.92 (95% CI: 0.89-0.94), a DOR of 45.46 and an AUC of 0.91 using CRC tissues to detect WIF1 methylation (Supplementary Figure 3).