WIF1 and colorectal carcinoma: In addition, WIF1 methylation was associated with CRC risk regardless of the tissue-based studies (P < 0.001, OR = 43.45, 95% CI = 15.38-122.73, Supplementary Figure 2) and feces-based and serum-based studies (P < 0.001, OR = 15.81, 95% CI = 7.74-32.26, Supplementary Figure 2).