By using the miRSystem, miR-142-3p was found a common predictive target of IL7R and KRAS. According to the relation between pivotal susceptibility genes and characteristic miRNAs, we hypothesized that miR-199a, miR-142-3p and their target genes (IL7R, KRAS) might act as MS therapeutic targets in the MAPK /JAK-STAT signaling transduction pathway. The gene discussed is KRAS; the disease is myeloid sarcoma.