We found that mean WSS (Table 5) and peak WSS (Supplementary Table 4) were strong and positively related to FMD and NO, and negatively related to ET-1, ICAM-1, and VCAM-1 after adjustment for confounders in Table 1, including age, sex, smoking, alcohol intake, body mass index, hypertension, antihypertensive medication, diabetes, lower glucose medication, dyslipidemia, anti-dyslipidemia medication, blood pressure, fasting blood glucose, blood lipids, and carotid artery plaque. Here, EDN1 is linked to metabolic syndrome.