SPARC and breast cancer: More interestingly, database search using the panel of seven genes (MUC1, PLAU, FABP7, SPARC, HAS2, HAS3, SOX4) downregulated by SAM revealed that these genes are highly expressed in basal B-type breast cancer cell lines and higher expression of these genes significantly decreases the probability of distant metastasis-free survival in breast cancer patients [42].