HPSE and cancer: Some other cancer-related genes that are induced by DNA hypomethylation include heparanase (HPSE) [10], synuclein-γ (SNCG) [11], pro-opiomelanocortin (POMC) [12], cadherin 3 (CDH3) [13], related RAS viral oncogene homolog (R-RAS) [14], maspin (also called SERPINB5) [15], and S100 calcium binding protein P (S100P) [15].