However, the number of interactions between REV3L and REV1, REV3L and MAD2L2, and REV1 and MAD2L2 were reduced to 44/cell, 27/cell, and 26/cell, respectively, in HCT-116 colon cancer cells and to 19.2/cell, 59/cell, the 51/cell in DLD-1 colon cancer cells. Here, REV3L is linked to malignant colon neoplasm.