An elevated level of TNFR2+Tregs is correlated with highly immunosuppressive microenvironment in malignant diseases, such as acute myeloid leukemia (AML) [19], lung cancer [20], and ovarian cancer [21], as well as in autoimmune disorders including type 1 diabetes and rheumatoid arthritis [22, 23]. This evidence concerns the gene TNFRSF1B and rheumatoid arthritis.