The expression level of Foxp3 was much higher in patients with CC (median=0.00045, range, 0.00003-0.00198, P<0.001) and patients with CIN (median=0.00050, range, 0.00006-0.00403, P<0.001) compared with healthy controls (median=0.00014, range, 0.00003-0.00122), but no significant difference was found between CC patients and CIN patients (P>0.05) (Figure 5D). This evidence concerns the gene FOXP3 and cervical squamous intraepithelial neoplasia.