In the present study, we examined the level of TNFR2+Tregs in both peripheral blood (PB) and tumor infiltrating lymphocytes (TILs), and relevant cytokines in patients with cervical intraepithelial neoplasia (CIN) III and different stages of CC. The gene discussed is TNFRSF1B; the disease is uterine cervix carcinoma in situ.