A recent study indicated that the isoleucine to methionine substitution at position 148 on patatin-like phospholipase domain-containing 3 (PNPLA3, adiponutrin) gene induced a gain of function in LPA-acyltransferase activity, leading to increased hepatic TG biosynthesis in HCC patients [34]. Here, PNPLA3 is linked to hepatocellular carcinoma.