MYC and ovarian carcinoma: As shown here, CAOV4 ovarian cancer cells, which overexpress MYC (Figure 2A), display increased levels of rRNA transcription (assessed as pre-rRNA) (Figure 2B) and upregulation of “Pol I regulon” genes (Figure 2C) relative to CAOV3 ovarian cancer cells, which do not overexpress MYC.