Further, based on the fact that MYC upregulation induces PTCD3, MRPS5, and MRPS27 proteins necessary for mitoribogenesis in MYC-overexpressing CAOV4 cancer cells, as well as in HFF fibroblast and different ovarian epithelial cell contexts with MYC overexpression, we tested if doxycycline, a tetracycline that targets the 28S subunit of mitochondrial ribosomes, was capable of reducing MYC-induced proliferation. Here, MRPS5 is linked to cancer.