Based on preliminary observations that ovarian cancer cells overexpressing MYC (CAOV4) displayed upregulation of POLRMT and mt-rRNA synthesis relative to ovarian cancer cells that do not overexpress MYC (CAOV3), we assessed the antiproliferative effects of targeting POLRMT-mediated mt-rRNA transcription in two human ovarian epithelial cell contexts (IOSE and HOSE), and in human fibroblasts (HFF) overexpressing MYC. The gene discussed is POLRMT; the disease is ovarian cancer.