POLRMT and ovarian carcinoma: We found evidence that, relative to CAOV3 ovarian cancer cells, which do not overexpress MYC, CAOV4 ovarian cancer cells, which overexpress MYC (see Figure 2A), display a) upregulation of both MYC-target genes involved in mt-rRNA transcription (POLRMT and TFAM) and MYC-target genes encoding mitoribosome proteins (PTCD3, MRPS5, MRPS27) (Figure 7A) as well as b) increased mitochondrial rRNA synthesis (Figure 7B).