Since CX-5461 was recently shown to have a positive effect on both chemoresistant ovarian epithelial cells and patient derived xenografts [36], it is possible that drugs targeting mt-rRNA and mitoribogenesis, when combined with drugs inhibiting Pol I like CX-5461, can be also effective in chemoresistant MYC-overexpressing cancer cell populations. This evidence concerns the gene MYC and cancer.