Considering OPN overexpression is ubiquitous in human cancers and HIF-1α is one of the most important transcriptional factors for malignant transformation of tumor cells, the OPN-induced and HIF-1α-mediated signaling cascade can be reasonably targeted for the prevention of OPN-induced EndoMT to inhibit cancer development and progression. The gene discussed is HIF1A; the disease is neoplasm.