Previously, we used BCL-2 overexpression to elucidate the involvement of microtubule damage-mediated G2/M arrest in microtubule damage-mediated apoptosis of human acute leukemia Jurkat T cells, in which the apoptotic pathways occurring upstream of BCL-2-sensitive mitochondrial apoptotic events are more prominently detected when the mitochondrial apoptotic pathway is blocked by BCL-2 overexpression [18–20]. This evidence concerns the gene BCL2 and acute leukemia.