To proof the models are successful, the BMD and BMC of the OVX- and sham-operated mice were examined using micro-CT (Figure 1A) and the bone mass were shown by H & E staining (Figure 1B) and the levels of TNF-α and IL-1β in the synovia in the IL-1β-induced arthritis mice and PBS-induced control mice were detected by ELISA (Figure 1F) and the bone mass were shown by H & E staining (Figure 1G). This evidence concerns the gene IL1B and arthritic joint disease.