The clinically relevant natural processing and presentation of three of the highly immunodominant epitopes (A*03_BILF2VTLA, A*03_BcRF1FLLA, A*03_BALF3QVAT) was confirmed by peptide-specific T-cell frequencies detected in HLA-A*03:01+ patients with EBV-associated PTLD. Here, HLA-A is linked to post-transplant lymphoproliferative disease.