The development of the hypoxic tumor microenvironment, which is associated with tumor progression and metastasis, depends on the presence of myeloid-derived suppressor cells (MDSCs) and tumor-associated macrophages (TAMs) [23, 24], and arises due to the generation of reactive oxygen species (ROS) and subsequent induction of HIF-1α expression [25, 26]. This evidence concerns the gene HIF1A and neoplasm.