In particular, CLU expression is regulated by metabolic signals, such as sterol regulatory element binding protein-1 (SREBP-1) [11–13], and hyperglycemia induces sCLU expression through the SREBP response element (SRE) but not by carbohydrate responsive element binding protein (ChREBP) in primary hepatocytes and hepatoma cell lines [14]. This evidence concerns the gene SREBF1 and Hyperglycemia.