Simultaneously, there were low levels of activity of ODC, ADC, SRM, SMS (spermine synthase, which catalyses the biotransformation of spermidine into spermine) and LYD as well as high levels of activity of OAZ1 and SAMDC (adenosyl methionine decarboxylase, a critical enzyme in the polyamine biosynthetic pathway that generates the active pyruvoyl group for the decarboxylation of acetyl-polyamines) in rats receiving therapy compared with control CRC rats. The gene discussed is SMS; the disease is colorectal carcinoma.