Very similar results were also observed in GR9-B7 tumor-bearing mice, with a significant decrease (p < 0.05) in TCD3+ (25.3 vs. 33.1%), mainly TCD4+ (19.7 vs. 26.1%), and TCD8+ (5.7 vs. 6.9%) lymphocytes, and a significant increase in Treg cells (6.9 vs. 4.4% of CD4 +) (Table 1). This evidence concerns the gene CD4 and neoplasm.