CD4 and neoplasm: In GR9-B7 tumor-bearing mice, treatments with PSK and PSK plus docetaxel produced a slight recovery in TCD3+ (32.2 and 26.0 vs. 25.3%, respectively) due to an increase in CD4+ lymphocytes (23.0 and 20.6% vs. 19.7%) vs. untreated tumor-bearing mice, but a significant increase in Treg cells (9.0 and 9.6 vs. 6.9%) was also observed (Table 1).