Very similar results were also observed in GR9-B7 tumor-bearing mice, with a significant decrease (p < 0.05) in TCD3+ (42.3 vs. 51.9%), mainly TCD4+ (35.1 vs. 40.6%), and TCD8+ (7.2 vs. 9.7%) lymphocytes, and a significant increase in Treg (5.8 vs. 2.9% of CD4+) (Table 1). Here, CD4 is linked to neoplasm.