In the GR9-A7 groups, immunotherapy and chemoimmunotherapy each produced a significant (p < 0.05) increase in TCD3+ lymphocytes (46.5, 58.0, and 36.6 vs. 30.4%) and in CD4+ (31.9, 44.2, and 30.1 vs. 24.4%) and CD8+ (14, 13.7, and 6.5 vs. 5.8%) T-cell subsets in comparison to untreated tumor-bearing mice, with a decrease in Treg cells (4.7, 9.5, and 1.1 vs. 10.8%) (Table 1). Here, CD4 is linked to neoplasm.