GR9-A7 tumor-bearing mice also showed a slight decrease in several immune cell subsets, with a reduction in TCD3+ lymphocytes vs. wild-type animals (43.3 vs. 51.9%) due to a decrease in TCD8+ (5.9 vs. 9.7%) and TCD4+ (37.4 and 40.6%) subpopulations; while a significant increase in Treg cells was observed (9.9 vs. 2.9% of CD4+). Here, CD4 is linked to neoplasm.