Surprisingly, however, the strongest overall association we observed based upon GWAS findings was between IL-1B/IL-36-increased genes and IBD (Figure 7A), with a total of 23 increased genes linked to IBD based upon GWAS findings, including ETS1, NOD2, FERMT1, and CXCL5 (Figure 7D). This evidence concerns the gene IL1B and inflammatory bowel disease.