This identified multiple autoimmune and/or autoinflammatory conditions for which associated genes overlapped significantly with IL-1B/IL-36-increased DEGs, including IBD/ulcerative colitis, psoriasis/PsA, systemic sclerosis, primary biliary cholangitis, atopic dermatitis, lupus, and rheumatoid arthritis (Figure 7A). The gene discussed is IL1B; the disease is systemic sclerosis.