The purpose of the present study was twofold: first, to explore the exact roles of miR-146a in the pathogenesis of EAAU, especially the relationships with NF-κB, and second, to determine whether local administration of miRNAs can be a new modality among the armamentarium of uveitis management, in which the local immunotherapy possesses a steroid-sparing character and is potentially devoid of systemic adverse effects. This evidence concerns the gene NFKB1 and uveitis.