ERBB2 and breast cancer: Glucose, whose utilization is critical for the generation of cellular energy, nucleic acids, and biomass, presented similar levels between the various breast cancer subtypes (p = 0.68, One-way ANOVA), whereas for the downstream glycolytic intermediates, a net accumulation could be observed in luminal B, basal, and HER2-enriched tissues in comparison to luminal A (see Figure 2).