Interestingly, even though IKK2 inhibition in OA- or RA-SFs is not sufficient to induce similar effects19, MG132, a potent NFκB modulator acting through proteosomal inhibition and suggested for the treatment of arthritis reviewed in64, provoked both RIPK1-mediated caspase-dependent and -independent death in SFs from some patients, providing translational evidence to our murine-based observations. Here, IKBKB is linked to rheumatoid arthritis.