TNF and rheumatoid arthritis: Interestingly, by looking at individual sample responses (Supplementary Figure 7D), we noticed that 2 out of 5 samples (40%) from both OA and RA patients have been partially rescued by each inhibitor treatment suggesting that the TNF/MG132-mediated effects are not limited to a caspase-mediated death but also includes another RIPK1-mediated cellular demise in the SFs of some patients.