INS and Insulin resistance: Chronic Ang II infusion caused insulin resistance as estimated by the ITT in WT mice, but this response was suppressed in TG mice (vehicle vs Ang II in WT mice; at 60 minutes after insulin injection, 54.6 ± 3.7 vs 84.5 ± 9.6 mg/dl, P = 0.006; at 120 minutes after insulin injection, 64.4 ± 3.0 vs 82.0 ± 7.2 mg/dl, P = 0.022; area under the curve, 8562 ± 425 vs 11045 ± 1068 min × mg/dl, P = 0.027) (Fig. 3a–d).