HSV-2 + Cc-Griffithsin also produced significantly more IL-6 at 4 hours post-infection compared to virus alone, although this was about 20% less IL-6 than what was produced by HSV-2 + Cc-A1AT, and not statistically significant when compared to HSV-2 + Cc-Control (Fig. 7c). Here, IL6 is linked to infection.