IFNG and infection: In comparison, although mice that received HSV-2 + Cc-Griffithsin had elevated IFNγ in the vaginal tract at 24 hours post-infection, this was not significantly greater than HSV-2 alone or HSV-2 + Cc-Control, and about a third the amount of IFNγ that the HSV-2 + Cc-A1AT mice produced (Fig. 7a).