This finding is consistent with previous work using an animal model of EAN, which showed that the IL-23 p19 RNA is upregulated prior to the onset of first clinical symptoms of GBS, with peak expression levels preceding maximum disease severity, and IL-23 p19 protein is detectable in CSF samples from GBS patients, and IL-23 p19 RNA levels decline significantly during the recovery phase15. The gene discussed is IL23A; the disease is Guillain-Barre syndrome.