EZH2 and neoplasm: Notably, three of the ranked apoptosis-regulating genes (DAB227, DLC128,29, and NOXA30) are known tumor suppressors that are implicated in suppressing proliferation and promoting apoptosis (Fig. 3b), i.e., the phenotypes we observed when CARM1 was knocked out or EZH2 activity was inhibited with GSK126 (Figs. 1,, 2).