Considering the similarities between AKI caused by sepsis and ischemia and reperfusion, the beneficial effect of CIRP inhibition with C23 on sepsis-induced AKI is supported by our previous study that showed decreased AKI after renal ischemia and reperfusion in rats treated with CIRP-neutralizing antibodies and in CIRP-deficient mice22. Here, CIRBP is linked to Sepsis.