GRN and frontotemporal dementia: Wnt signalling has been implicated in FTD with GRN mutations,30 31 and targeting the Wnt signalling pathway may emerge as a future therapeutic.36 In addition to apoptosis and Wnt signalling, mRNA targets were found in other biological pathways that have been linked with neurodegeneration and/or FTD such as MAPK signalling,37 endocytosis,38 39 notch signalling40 and neurotrophin signalling.41 42